Circulatory Failure, Fluid Overload, Fluid Responsiveness, Respiratory Failure
Conditions
Brief summary
The study investigates the influence of a clinically indicated fluid challenge on end-expiratory lung impedance, assessed by electrical impedance tomography (EIT). EIT data will be collected before, during and after infusion of 500 ml of crystalloid solution in mechanically ventilated patients on an operative intensive care unit.
Interventions
OTHERFluid Challenge
Infusion of a standardized amount of crystalloid solution (500 ml) to assess fluid responsiveness by means of changes in cardiac output, assessed by transpulmonary thermodilution.
Sponsors
University Hospital Schleswig-Holstein
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients on mechanical ventilation * clincial decision to monitor regional ventilation with electrical impedance tomography * clinical indication for fluid challenge * established cardiac output monitoring with transpulmonary thermodilution
Exclusion criteria
* age \< 18 years * open lung injuries * instable injury of spine or cranium * thoracic metal implants * body mass index \> 35
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in end-expiratory lung impedance (EELI) | 15-30 minutes | To assess the effect of fluid challenge on EELI, the change in EELI during the fluid challenge will be measured by electrical impedance tomography and will be compared to the change in EELI during the last 15 minutes before start of the fluid challenge. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between change in end-expiratory lung impedance and change in intrathoracic blood volume | 15-30 minutes | We will assess the correlation between the change in end-expiratory lung impedance during infusion of 500 ml of crystalloid solution and the change in intrathoracic blood volume (assessed by transpulmonary thermodilution) during the same time period. |
| Fluid responsiveness | 15-30 minutes | We will investigate whether the ratio of cardiac-related impedance changes to ventilation-related impedance changes, measured by EIT at baseline (i.e. before start of fluid challenge), can predict fluid responsiveness, defined as an increase in stroke volume of greater or equal to 15% compared to baseline. |
Countries
Germany
Outcome results
None listed