Cancer, Breast, Cancer, Colorectal, Cancer, Lung, Cancer, Ovarian
Conditions
Keywords
exercise, neuropathy
Brief summary
Chemotherapy-induced peripheral neuropathy (CIPN) continues to be a serious healthcare concern. It is painful, persistent, resistant to conventional pain therapies, and results in long-term suffering and decreased quality of life for many cancer survivors. The role of exercise to decrease CIPN-related neuropathic pain (CIPN-NP) will be investigated, with the goal of identifying the mechanisms associated with this therapeutic approach to manage CIPN-NP.
Interventions
BEHAVIORALaerobic exercise intervention
Exercise physiologist supervised walking or running on the treadmill 3 times weekly for 12 weeks.
OTHERcontrol group
weekly contact by study staff with survivorship information offered not related to neuropathy.
BEHAVIORALresistive training
Exercise physiologist supervised upper and lower extremity resistive training 3 times weekly for 12 weeks
Sponsors
Baltimore VA Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
21 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis with cancer, stage I-IV * History of treatment with oxaliplatin, docetaxel, or paclitaxel, either alone or in combination with other agents * Completion of chemotherapy \> 6 months \< 1 year * Ability to walk on a treadmill * Medical clearance from oncologist or primary care provider * Presence of CIPN per National Cancer Institute Common Toxicity Criteria grade 1-3 (0-no signs/symptoms, 1-minor loss of function, 2-increased symptoms not interfering with activities of daily living (ADLs), 3-severe symptoms interfering with ADL, 4-disabling, and 5 is death) * Score on Neuropathic Pain Scale \>1 * Age 21-70
Exclusion criteria
* Denial of CIPN * Other motor/sensory neuropathy caused by other than chemotherapy (i.e.alcohol-related, autoimmune diseases, diabetes) * Coronary artery disease * History of \>1 chemotherapy regimen * Musculoskeletal conditions which preclude participation in an exercise training program * Pregnancy * Regular exerciser, defined as \>90 minutes per week of aerobic exercise and any resistive training
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sensory pain | 13 weeks | Thermal, mechanical, and vibration sensation by quantitative sensory testing |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Nerve fiber density | 13 weeks | laboratory examination of skin biopsy samples for measurement of nerve fiber density |
Countries
United States
Outcome results
None listed