MI Related Malignant Ventricular Arrhythmia
Conditions
Keywords
myocardial infarction, ventricular arrhythmia, radiofrequency ablation, Coronary Artery Bypass Grafts
Brief summary
Patients with myocardial infarction related potential malignant ventricular arrhythmia have high risk of sudden death. The aim of this clinical trial is evaluating therapeutic efficacy of unipolar or bipolar radiofrequency ablation in Coronary Artery Bypass Grafts (CABG) Surgery, which can reduce myocardial ischemia and block reentry circuits of ventricular arrhythmia at the same time. The observation indexes include the morbidity of potential malignant ventricular arrhythmia and major adverse cardiovascular events in mid-long-term after CABG surgery.
Interventions
PROCEDUREunipolar or bipolar radiofrequency ablation+CABG
Patients with myocardial infarction related potential malignant ventricular arrhythmia undergoing unipolar or bipolar radiofrequency ablation and Coronary Artery Bypass Grafts at the same time
PROCEDURECABG
Patients with myocardial infarction related potential malignant ventricular arrhythmia undergoing Coronary Artery Bypass Grafts
Sponsors
Xuanwu Hospital, Beijing
Beijing Chao Yang Hospital
Beijing Anzhen Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
45 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* The patients have been receiving coronary artery bypass grafts from 2015.1-2017.12 * The patients had old myocardial infarction related potential malignant ventricular arrhythmia * Anti-arrhythmic drug treatment is invalid * All enrolled patients must being signed the informed consent
Exclusion criteria
* Severe heart failure( ejection fraction under 35%) * Patients with acute myocardial infarction * Patients with ICD implanted
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Morbidity of potential malignant ventricular arrhythmia | 1 year after surgery | The morbidity of potential malignant ventricular arrhythmia in 1 year after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Morbidity of major adverse cardiovascular events | 1 year after surgery | The morbidity of the major adverse cardiovascular events in 1 year after surgery |
Other
| Measure | Time frame | Description |
|---|---|---|
| Cardiac function | Change from Baseline Cardiac Function at 3 month, 6 month, 1 year, 2 year after surgery | Change from Baseline Cardiac Function evaluated by echocardiography at 3 month, 6 month, 1 year, 2 year after surgery |
| Cardiac electrophysiology index | Change from Baseline Cardiac Electrophysiology Index at 1 year and 2 year after surgery | Change from Baseline Cardiac Electrophysiology Index evaluated by Holter and cardiac magnetic resonance imaging or CARTO at 1 year and 2 year after surgery |
| Seattle Angina Questionnaire | Change from Baseline Seattle Angina Questionnaire at 3 month, 6 month, 1 year, 2 year after surgery | Change from Baseline the Seattle Angina Questionnaire at 3 month, 6 month, 1 year, 2 year after surgery |
Countries
China
Outcome results
None listed