Subarachnoid Hemorrhage, Aneurysmal
Conditions
Keywords
cerebral vasospasm, nimodipine
Brief summary
This prospective observational study will assess the regional cerebral oxygen saturation and cardiac output non-invasively in patients with subarachnoid hemorrhage during nimodipine administration for the prevention/management of cerebral vasospasm.
Interventions
DRUGNimodipine
Sponsors
National Institute of Mental Health and Neuro Sciences, India
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* aneurysmal subarachnoid hemorrhage * potential or actual cerebral vasospasm
Exclusion criteria
* non-aneurysmal subarachnoid hemorrhage * outside the 4-21 day window after ictus * peripheral deoxygenation * contraindication for nimodipine administration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in the cerebral oxygen saturation percentage measured using near infrared spectroscopy technology after administration of nimodipine | Change from baseline cerebral oxygen saturation at 30 minutes after administration of nimodipine |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in the cardiac output measured using near NICOM technology after administration of nimodipine | Change from baseline cardiac output at 30 and 240 minutes after administration of nimodipine | unit of measurement will be L/min |
| Change in the cerebral oxygen saturation percentage measured using near infrared spectroscopy technology after administration of nimodipine | Change from baseline cerebral oxygen saturation at 240 minutes after administration of nimodipine | — |
Countries
India
Outcome results
None listed