The Effect of Olive Leaf Extract Administration on Cardiovascular Health

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02990637

Enrollment

Registered

2016-12-13

Start date

2016-06-30

Completion date

2017-04-30

Last updated

2017-05-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elevated Cholesterol, Overweight and Obesity

Keywords

Olive leaf extract, Cardiovascular health, Cholesterol

Brief summary

The purpose of this study is to investigate the effects of daily supplementation of OLECOL for a period of 8 weeks on cardiovascular risk markers.

Interventions

DIETARY_SUPPLEMENTOLECOL

Olive leaf extract

DIETARY_SUPPLEMENTPlacebo

Maltodextrin

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy individuals * Age between 18 and 70 years * Total cholesterol levels ≥ 5.0 mmol/L * BMI 25-35 kg/m2

Exclusion criteria

* History of severe cardiovascular, respiratory, urogenital, gastrointestinal/hepatic, hematological/immunologic, HEENT (head, ears, eyes, nose, throat). Dermatological/connective tissue, musculoskeletal, metabolic/nutritional, endocrine, neurological diseases, allergy, major surgery and /or laboratory assessments that might limit participation in or completion of the study protocol. * Diabetes * Use of medication that might have influence on endpoints (e.g. cholesterol lowering medication, hypertension medication) * Administration of investigational drugs or participation in any scientific intervention study which may interfere with this study in the 180 days prior to the study * Use of antibiotics in the 30 days prior to the start of the study * Use of antioxidants, minerals and vitamin supplements available in pharmacies, drugstores, food markets or in alternative medicine * Pregnancy, lactation * Abuse of products (\> 20 alcoholic consumptions per week and drugs) * Smoking * Weight gain or loss (\> 3 kg in previous 3 months) * High physical activity (\>4.5 hours of running/week) * History of any side effects towards intake of olives

Design outcomes

Primary

Measure	Time frame
Blood lipid profile	8 weeks

Secondary

Measure	Time frame
Lipid peroxidation	8 weeks
Glucose metabolism	8 weeks
Systolic and diastolic blood pressure	8 weeks

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 17, 2026