Recurrent Pregnancy Loss
Conditions
Brief summary
In this clinical cohort study, the investigators are going to observe the efficacy of anti-coagulation and immune therapy in the treatment of recurrent pregnancy loss with a prospective randomized controlled trial.
Interventions
Sponsors
Shanghai First Maternity and Infant Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
\- Woman who had 2 miscarriage before 12(th) week of gestation.The patient who is diagnosed as thrombophilia with recurrent pregnancy loss. Signed consent form.
Exclusion criteria
1. having experienced severe allergies, trauma history and/or operation history within 3 months. 2. with a history of mental illness and/or family history of mental illness limb disabled. 3. taking medicine within one month. 4. suffering major events or having mood swings. 5. having internal and surgical disease(after having variety of physical examination such as electrocardiogram/hepatic and renal function/blood routine and urine routine) 6. chromosome aberrations in anyone of the couple. 7. patients who have drugs contraindications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| live birth | through study completion, an average of 3 year | live birth means success pregnancy（more than gestational age of 20 weeks） |
Secondary
| Measure | Time frame |
|---|---|
| D-dimer | through study completion, an average of 3 year |
| Uterine artery blood flow | through study completion, an average of 3 year |
| human chorionic gonadotropin | through study completion, an average of 3 year |
Countries
China
Outcome results
None listed