Recurrent Pregnancy Loss
Conditions
Brief summary
RSA is a multifactorial disorder resulting from genetic factors, anatomic factors, autoimmune disorders, endocrine dysfunction, thrombophilia, life style factors, and maternal infections. However, the underlying causes remain undetermined in up to 50% of cases. In this clinical cohort study, we intended to get an epidemiological evidence for patients with recurrent spontaneous abortion associated with thrombophilla.
Interventions
None listed
Sponsors
Shanghai First Maternity and Infant Hospital
Study design
Observational model
COHORT
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Woman who had 2 miscarriages before 12(th) week of gestation.Signed consent form.
Exclusion criteria
1. having experienced severe allergies, trauma history and/or operation history within 3 months; 2. with a history of mental illness and/or family history of mental illness 3. limb disabled 4. taking medicine within one month 5. suffering major events or having mood swings 6. with a history of recurrent pregnancy loss 7. having internal and surgical disease(after having variety of physical examination such as electrocardiogram/hepatic and renal function/blood routine and urine routine) 8. chromosome aberrations in anyone of the couple.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| D-Dimer | through study completion, an average of 3 year |
Secondary
| Measure | Time frame |
|---|---|
| BMI in kg/m^2 | through study completion, an average of 3 year |
| platelet aggregation time | through study completion, an average of 3 year |
| anticardiolipin antibody | through study completion, an average of 3 year |
Countries
China
Outcome results
None listed