Hepatocellular Carcinoma (HCC), Living Donor Liver Transplantation
Conditions
Brief summary
This study aimed to analyze the outcomes of loco-regional treatment prior Living Donor Liver Transplantation in patients with HCC.
Detailed description
50 patients received LDLT at Ain Shams Centre for Organ Transplantation (ASCOT) over 1 year of whom data of 29 HCC patients were analyzed. Twenty patients met the Milan criteria (68.97%) & 4 (13.8%) were beyond Milan but met UCSF criteria and 5 were exceeding UCSF criteria (17.2%).All patients underwent preoperative LRTs, The protocol of bridging/down staging, methods, duration of follow up, the number of the patients who were successfully down-staged before LT and their outcomes after LT were recorded.
Interventions
PROCEDUREloco regional therapies for HCC
29 HCC patients received locoregonal therapy as a bridging therapy for those who were within milan and as downstaging for those were initially beyond milan. The main LRT types used for our patients were TACE and or RFA and microwave ablation
Sponsors
Ain Shams University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. Adult patients 18-65 years 2. Patients transplanted for HCC within Milan and UCSF criteria who underwent pre transplant bridge or down staging treatment for HCC
Exclusion criteria
1. Tumor progression on the waiting list 2. Vascular invasion by imaging studies 3. Extrahepatic or lymph node metastasis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Radiological Response ( complete / partial / tumour progression)in the Radiology (CT/ MRI) before transplantation | 3 months | the success of loco-regional therapy for hepatocellular carcinoma in term of radiological complete or partial response in the last spiral triphasic abdominal CT and /or MRI before transpalantation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the degree of accuracy between the last CT/ MRI and the pathology of explant in term of number , size and ablation (complete necrosis ) for HCC | 3 months | 1. presence of viable tumour tissue in the explant pathology, 2. mictro vascular invasion 3. capsular or lymph node invasion the degree of accuracy between the last CT/ MRI and the pathology of explant |
Outcome results
None listed