Concussion
Conditions
Brief summary
This study assess the putative persistence of neural damage using resting state fMRI after concussion in rugby player once they have clinically recovered. The hypothesis is that despite a clinical recovery (absence of symptoms; neurological and neuropsychological examination returned to normal) connectivity map obtained using resting state fMRI are significantly different from a group of control subjects.
Detailed description
Resting state fMRI has shown to be a sensitive tool to assess neural damage after concussion. It seems more sensible than structural MRI including DTI. the study goal will be to assess rugby players using fMRI at 3 different times after concussion: just after concussion (V1), once players have clinically recovered (V2) and 3 months after V2 (V3). The study would specifically like to challenge clinical examination supposed to be normal at V2 to connectivity maps using resting state fMRI preformed at the same time. fMRI performed at V1 and V3 will serve as comparators (respectively very altered at V1 and back to normal at V3).
Interventions
DEVICEfMRI
fMRI at 3 different times after concussion: just after concussion (V1), once players have clinically recovered (V2) and 3 months after V2 (V3).
Sponsors
University Hospital, Toulouse
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* no neurological or psychiatric disease * recent history of concussion (\<3 months) according to the Rugby French Federation criteria.
Exclusion criteria
* Inability to be assessed by MRI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Difference of connectivity maps between the players with concussion and the group control | up to 1 month | connectivity maps obtained during a 10 minutes resting state fMRI at V2 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Difference of connectivity maps between the players with concussion and the group control | up to 3 months | Connectivity maps obtained during a 10 minutes resting state fMRI at V1 and V3 |
| neuropsychological questionnaire | up to 3 months | Scores obtained the neuropsychological assessment. Memory, attention and executive functions will be assessed using validated tools. |
| neurophysiological data | up to 3 months | Structural imaging data (DTI) |
Countries
France
Outcome results
None listed