Uterus Transplantation From Live Donors With Robotic Assisted Surgery - Gothenburg II

Conditions

Infertility, Female

Keywords

infertility, uterus, transplantation

Brief summary

The study is a follow up of NCT01844362. Uterus transplantation will be performed from live donors to patients with uterine factor infertility. If will be performed before transplantation. Organ procurement from the donor will be performed by robotic assisted laparoscopy. Transplantation will be by laparotomy. Embryo transfer will be done 10-12 months after transplantation. After birth of 1-3 children the uterus will be removed by hysterectomy,

Detailed description

The study is a follow up of NCT01844362. Uterus transplantation will be performed from live donors to patients with uterine factor infertility. If will be performed before transplantation. Organ procurement from the donor will be performed by robotic assisted laparoscopy. Transplantation will be by laparotomy. Embryo transfer will be done 10-12 months after transplantation. After birth of 1-3 children the uterus will be removed by hysterectomy.

Wentz E, Hagberg B, Hagberg H, Bokström H, Brännström M.

2025-12-01

10.1093/humrep/deaf178

Reproductive, obstetric, and long-term health outcome after uterus transplantation: results of the first clinical trial.

Brännström M, Dahm-Kähler P, Kvarnström N, Enskog A, Olofsson JI, Olausson M, Mölne J, Akouri R, Järvholm S, Nilsson L, Stigson L, Hagberg H, Bokström H.

2022-06-1134 citations

10.1016/j.fertnstert.2022.05.017

Evolution of surgical steps in robotics-assisted donor surgery for uterus transplantation: results of the eight cases in the Swedish trial

Mats Brännström, Niclas Kvarnström, Klaus Groth, Randa Akouri, Lennart Wiman et al. (7 authors)

Fertility and Sterility2020-08-1951 citations

10.1016/j.fertnstert.2020.05.027

Interventions

PROCEDUREuterus transplantation

Uterus transplantation from live donor

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 38 Years

Healthy volunteers

Yes

Inclusion criteria

* age below 38 years * absolute uterine factor infertility * BMI\<30

Exclusion criteria

* systemic disease * psychiatric disease

Design outcomes

Primary

Measure	Time frame	Description
Live births after uterus transplantation	5 years	Assessed by records from birthing unit and Swedish National Birth registry

Secondary

Measure	Time frame	Description
Development of children after uterus transplantation	8 years	Assessed by growth parameters and neuropsychiatric tests (Bayley Mental Scale, M-CHAT, CBCL, WPPSI-IV)

Countries

Sweden

Outcome results

None listed