Dementia, Malocclusion
Conditions
Keywords
Dental Occlusion, Oral Health, Mastication, Dementia, Psychological health
Brief summary
Oral health is a critical factor of systemic health, although usually forgotten. A potential relation between cognitive deficits and oral diseases has been suggested. Adult cognitive dysfunctions have a high impact, not only economic, but social and in the family environment. Based on anatomical connectivity between the oral cavity and the central nervous system, the proposed study hypothesizes that masticatory function is a relevant determinant of human cognitive health. The restoration of canonical masticatory function and masticatory training could help to delay the development of such conditions. This project will also test if restoring phasic masticatory function improves the execution of cognitive tasks.
Detailed description
Objective 1: To determine volumetric and anatomical changes of subcortical structures and cortical areas involved in the masticatory circuit and superior cognitive functions. Objective 2: To determine the functional and brain connectivity changes associated with malocclusion and oral health. Objective 3: To correlate the anatomic and functional changes associated with malocclusion and oral health with the performance of cognitive tasks representative of those executed in daily life.
Interventions
PROCEDUREDental occlusion restoration
Placement of dental implants by surgical intervention followed, after a healing period of 2 months, by fabrication and installation of implant supported dental prosthesis
PROCEDUREOrthodontic treatment of malocclusion
Orthodontic therapy to treat malocclusion
Sponsors
Universidad de Granada
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* For Dental occlusion restoration groups: Need of, at least, two molar teeth replacement in the same quadrant. * For Orthodontic treatment of malocclusion groups: Class I, II or III malocclusion.
Exclusion criteria
* Psychoactive drug. * Central nervous system depressor. * Patients not willing or not able to consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of occlusion units | Baseline, 6, 12 and 36 months | Number of teeth occluding with opposing teeth |
| Change of cerebral activity | Baseline, 6, 12 and 36 months | Functional MRI |
| Change of cognitive function | Baseline, 6, 12 and 36 months | Verbal fluency |
| Change of frame of mind | Baseline, 6, 12 and 36 months | Beck test |
| Change of resting brain activity | Baseline, 6, 12 and 36 months | Electroencephalographic activity |
Countries
Spain
Contacts
PRINCIPAL_INVESTIGATORPablo Galindo-Moreno, DDS, PhD
Universidad de Granada
Outcome results
None listed