The Metabolomics of Intestinal Polyps of Different Pathological Types and TCM Syndromes and TCM Constitution Types

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02986308

Enrollment

1659

Registered

2016-12-08

Start date

2016-06-13

Completion date

2019-02-19

Last updated

2020-02-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intestinal Polyps

Keywords

Metabolomics, Intestinal Polyps, TCM Syndromes, TCM Constitution Types

Brief summary

The aim of this study is to confirm the TCM syndrome types and TCM constitution classifications of the patients with intestinal polyps via on-site epidemiological survey, to analyze metabolomics of the serum samples of intestinal polyps and healthy volunteers, and to study the metabolomics differences of the two populations and the metabolomics variations of the patients with intestinal polyps of pre-polypectomy and post-polypectomy. Finally, this study is to investigate the serum metabolomics variations of patients with intestinal polyps of pre-polypectomy and post-polypectomy and the relationship with their TCM syndrome types and TCM constitution classifications, to determine the correlation among pathology, TCM constitution, TCM syndrome types and the metabonomics variations of patients with intestinal polyps.

Interventions

OTHERNo intervention

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

1. Age 20 to 80,all genders; 2. Intestinal polyps were found by colonoscopy; 3. The patients are scheduled for polypectomy; 4. Preoperative examinations were completed; 5. Performance status 0-1; 6. Diet has well controlled prior to the operation; 7. Patients or their statutory agent have signed the informed consent forms.

Exclusion criteria

1. The patient has not diagnosed by colonoscopy; 2. The patient has surgical contraindication; 3. Patients in pregnant or lactational period ; 4. Psychopath; 5. The patient is in drug trial.

Design outcomes

Primary

Measure	Time frame
Aiming to obtain biomarker groups of different pathological types of intestinal polyps, The potential biomarkers will be entered KEGG database to obtain metabolic pathways.	2 years

Secondary

Measure	Time frame
All data matrices are introduced to Ezinfo software for PCA and OPLS-DA. Using improved MetPA enriched pathways method to discover the metabolic pathways of the disease.	3 days

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 1, 2026