How Does Altering the Timing of Pre-exercise Low-dose Caffeine Ingestion Affect Endurance Exercise Performance

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02985606

Enrollment

Registered

2016-12-07

Start date

2016-11-30

Completion date

2018-09-15

Last updated

2018-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Brief summary

Investigate how manipulating the time between caffeine ingestion and exercise may alter exercise performance and cognition

Interventions

OTHERCaffeine powder -60

OTHERCaffeine powder -30

OTHERCaffeine powder 0

OTHERPlacebo powder -60

OTHERPlacebo powder -30

OTHERPlacebo powder 0

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* vo2max \> 55 ml/kg/min * females on contraceptive pill

Exclusion criteria

* recent skeletal muscle injury * cardiovascular injury * metabolic disease

Design outcomes

Primary

Measure	Time frame
Work done in kilojoules (kJ) during a 15 minute time trial on a cycle ergometer	15 minutes

Secondary

Measure	Time frame
Whole body fuel substrate utilisation measured using indirect calorimetry	10 minutes
Change in plasma caffeine concentration and metabolites	2 hours 45 minutes
Change in cognitive function measured using stroop test	2 hours 45 minutes
Collection of saliva for genotyping of CYP1A2	30 mintes

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 27, 2026