Type1diabetes
Conditions
Brief summary
Brown adipose tissue has the capacity to consume large amounts of energy and has insulin-independent glucose uptake. The investigators have recently observed an inverse correlation between irisin levels and insulin needs of type 1 diabetes patients. Transplantation of brown adipose tissue to insulin-deficient rats normalized their blood glucose levels. In this study 12 patients with long-standing type 1 diabetes (\>10 years) and with variable exogenous insulin needs will be investigated for amount of brown adipose tissue with positron emission tomography using the tracer 18F-deoxy glucose.
Interventions
RADIATIONPositron emission tomography with tracer 18F-deoxy glucose
Assessment of activity of brown adipose tissue with positron emission tomography using the tracer 18F-deoxy glucose
Sponsors
Per-Ola Carlsson
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Adult patients (18 years of age or more) 2. Type 1 diabetes diagnose for more than 10 years
Exclusion criteria
1. Ongoing pregnancy 2. Ongoing breast-feeding 3. BMI\<19 4. BMI \>30 5. P-creatinine \<110 µmol/l
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Activity of brown adipose tissue in correlation to exogenous insulin needs using the tracer 18F-deoxy glucose in positron emission tomography measurements | Assessment performed after more than 10 years of diagnosed type 1 diabetes |
Secondary
| Measure | Time frame |
|---|---|
| Glucose uptake in muscle in correlation to exogenous insulin needs; assessment using the tracer 18F deoxy glucose in positron emission tomography measurements. | Assessment performed after more than 10 years of diagnosed type 1 diabetes |
Countries
Sweden
Outcome results
None listed