Healthy
Conditions
Brief summary
Compare chronic (one week) of a 'normal' meat diet with one week of mycoprotein consumption, with or without a reduced nucleotide content, on markers of metabolic health, such as uric acid concentrations, blood glucose control and blood lipid profiles.
Interventions
OTHERAnimal protein based diet
OTHERLow-nucleotide mycoprotein based diet
OTHERHigh-nucleotide mycoprotein based diet
Sponsors
University of Exeter
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI between 18 and 30
Exclusion criteria
* On medication (except contraception) * Smokers * Diagnosed with any metabolic or cardiovascular conditions * BMI \< 18 or \> 30 * Dietary restrictions (vegetarians/vegans, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum uric acid concentrations | Measured at baseline; days 2, 4 and 6 of the intervention; and after the 1 week intervention (day 8) |
Secondary
| Measure | Time frame |
|---|---|
| 24 h blood glucose homeostasis - measured using a Dexcom CGMS | Measured 5 days at baseline (habitual data) and 5 days during the intervention (days 3 - 7) |
| Metabolomics (using Nuclear Magnetic Resonance - NMR) | Measured at baseline; days 2, 4 and 6 of the intervention; and after the 1 week intervention (day 8) |
| Glycaemia and serum insulin - insulin sensitivity (oral glucose tolerance test) | Measured at baseline and after 1 week intervention (day 8) |
| IL-6 | Measured at baseline and after 1 week intervention (day 8) |
Outcome results
None listed