Adenovirus, Cardiovascular Diseases, Human Metapneumovirus Pneumonia, Influenza, Human, Parainfluenza, Respiratory Syncytial Virus Infections, Rhinovirus
Conditions
Brief summary
This study will investigate whether there is a population-level association between circulating respiratory viruses and NHS hospital admissions for acute vascular events using data from national infection surveillance and Hospital Episode Statistics.
Detailed description
We will conduct a time series study correlating anonymised population level data on all samples from NHS laboratories testing positive for six common respiratory viruses with admissions to NHS hospitals in England for a range of cardiac and vascular outcomes over the time period 01/01/2004 to 31/12/2014. This will involve generating Poisson regression models controlling for factors such as seasonal and long-term trends, environmental temperature and humidity. This study is funded by an Academy of Medical Sciences Starter Grant for Clinical Lecturers.
Interventions
None listed
Sponsors
Public Health England
University College, London
Study design
Observational model
ECOLOGIC_OR_COMMUNITY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
45 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Any individual with a record of an eligible outcome (ICD-10 coded hospitalisation for myocardial infarction or stroke) within the study period aged 45+ years * Any individual with a record of an eligible exposure (laboratory-confirmed respiratory virus) within the study period at any age
Exclusion criteria
* Outcome events occurring in people aged \<45 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acute myocardial infarction | 01/01/2004 to 31/12/2014 | ICD-10 coded |
| Stroke | 01/01/2004 to 31/12/2014 | ICD-10 coded |
Countries
United Kingdom
Outcome results
None listed