Acute Bronchiolitis
Conditions
Keywords
Acute bronchiolitis, RSV, CC16, SP-D, sRAGE, Severity, Biomarkers
Brief summary
Acute bronchiolitis is a common viral infection in infants mainly due to RSV and rhinovirus. Biomarkers can be useful for predicting its severity. The serum CC16 is a marker of epithelial aggression. Its rate increase during RSV bronchiolitis in infants less than 7 months. It could be an early predictive biomarker of the severity of acute bronchiolitis, and secondarily for the development of asthma. Two other markers of airway aggression seem to increase during acute bronchiolitis: serum SP-D protein and serum soluble receptor sRAGE.
Detailed description
Prospective, monocentric, case-control and study Primary end-point: correlation between serum CC16 level and severity of the bronchiolitis, evaluated by a clinical scoring system established at the time of the admission in Paediatric Emergency Unit. Secondary end-points: correlation with urinary CC16; correlation with risk factors for bronchial epithelial aggression, viruses, immediate morbidity and mortality. Study of serum SP-D and sRAGE levels.
Interventions
DRUGProtein CC16
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Days to 1 Years
Healthy volunteers
Yes
Inclusion criteria
* Infants under 1 year old hospitalized for acute bronchiolitis
Exclusion criteria
* Broncho dysplasia * Preterm under 34 weeks * Cystic fibrosis * Immune deficiency * Suspicion of primary ciliary dyskinesia * Congenital heart disease * Acute renal failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum CC16 rate | at day 1 |
Secondary
| Measure | Time frame |
|---|---|
| Urinary CC16 rate | at day 1 |
| SP-D rates | at day 1 |
| sRAGE rates | at day 1 |
Countries
France
Contacts
Primary ContactPatrick LACARIN
Outcome results
None listed