Drug Hypersensitivity
Conditions
Brief summary
Patients labeled as penicillin allergic, rarely have this confirmed and being labeled as penicillin allergic is associated with increased health care costs, adverse effects and antibiotic resistance. The investigators will recruit participants from primary care practices labeled as penicillin allergic and offer allergy testing. The aim of this study is to develop a community, outpatient program for evaluation of penicillin allergy.
Interventions
OTHERPenicillin allergy testing
The standard protocol for testing for penicillin hypersensitivity, including initial skin testing with prick and intradermal evaluation followed by oral challenge if skin testing is negative.
Sponsors
Albany Medical College
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Labeled as having penicillin or amoxicillin allergy 2. Family history of penicillin allergy
Exclusion criteria
1. History of beta-lactam associated toxic epidermal necrolysis/Stevens Johnson syndrome to penicillin or amoxicillin 2. History of Drug induced Eosinophilia with Systemic Symptoms (DRESS) 3. History of drug induced: autoimmune hepatitis/interstitial nephritis, or hemolytic anemia 4. Poorly controlled asthma or heart disease 5. Currently pregnant 6. Unable to discontinue certain medications that may interfere with testing including (antihistamines, steroids, beta-blockers, tricyclic antidepressants, omalizumab)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Allergy testing for penicillin allergy results | 6 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Participant satisfaction after allergy testing with follow-up questionnaire | Within 6 months following testing | A questionnaire will be provided to participants to review their experience with penicillin allergy testing, whether they will take penicillin in the future and if it is valuable information to be tested. Answers will be yes and no. This information will tell us |
| Development of new drug allergies following negative testing questionnaire | 6 months-2 years | Follow-up questionnaire will be sent to participants to evaluate whether they have needed any antibiotics and if so, whether they've had any reactions. This will be two yes/no questions to assess the incidence of development of new allergic reaction following negative testing. |
Countries
United States
Outcome results
None listed