Hereditary Haemorrhagic Telangiectasia (HHT)
Conditions
Brief summary
Hereditary haemorrhagic telangiectasia (HHT), also known as Rendu-Osler-Weber syndrome, is an inherited multisystemic disorder. Literature suggests that HHT is often associated with higher frequency of infectious diseases. The purpose of this study is to evaluate a variety of immunologic parameters in the blood serum of HHT patients in comparison to probands.
Detailed description
Hereditary haemorrhagic telangiectasia (HHT), also known as Rendu-Osler-Weber syndrome, is an inherited multisystemic disorder with recurrent epistaxis, mucocutaneous telangiectasia and visceral arteriovenous malformations. Literature and the investigators' observation suggest that HHT is often associated with higher frequency of infectious diseases. This might be a hint for a immunocompromised situation. The purpose of this study is to evaluate a variety of immunologic parameters in the blood serum of HHT patients in comparison to probands.
Interventions
OTHERblood sample
none, only laboratory tests on blood serum
Sponsors
University Hospital, Essen
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* aged 18 or over, HHT
Exclusion criteria
* Unable to provide informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amounts of leucocytes in patients with HHT | November 2016 - December 2018 |
Secondary
| Measure | Time frame |
|---|---|
| Differences in distribution of leucocytes in patients with HHT | November 2016 - December 2018 |
Other
| Measure | Time frame |
|---|---|
| Functional properties of leucocytes in patients with HHT | November 2016 - December 2018 |
| Differences in size of leucocytes in patients with HHT | November 2016 - December 2018 |
Countries
Germany
Outcome results
None listed