Drug Resistant Epilepsy
Conditions
Keywords
Children, IQ, Idiopathic epilepsy, Magnesium supplementation, Seizure control, Chalfont score
Brief summary
Effect of oral magnesium sulfate (Mg) supplementation will be studied. Children with drug resistant idiopathic epilepsy following up in Pediatric Neurology Clinic, Ain Shams University, will be randomized to either Mg add-on treatment group or anti-epileptic drugs AEDs alone. Serum magnesium, seizure control and Intelligent quotation (IQ) will be done at base line and after 6 months of treatment.
Detailed description
The Aim of this work was to study the effect of Magnesium as add on therapy on clinical seizure control in drug resistant idiopathic epilepsy and IQ.
Interventions
DIETARY_SUPPLEMENTMagnesium
Oral magnesium
Placebo will be given
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
6 Years to 16 Years
Healthy volunteers
No
Inclusion criteria
* Children with drug resistant idiopathic epilepsy
Exclusion criteria
* Structural, Metabolic, Infectious and Unknown etiology epilepsy * Any neurological disease other than epilepsy * Any nutritional disorder * Any other systemic diseases (including Renal disease, Cardiac arrhythmia) * Drug intake other than antiepileptic drugs (AED)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Seizure control | 6 months | Change from base line seizure frequency, severity (Chalfont scale) at 6 months. |
| IQ improvement | 6-months | Change from base line IQ (Wechsler Intelligence Scale-Revised for Children and Adults) |
Countries
Egypt
Outcome results
None listed