Optic Neuropathy
Conditions
Keywords
glaucoma, Leber optic neuropathy, anterior ischemic optic neuropathy
Brief summary
The participant is being asked to be a subject in this research study because the participant may have a disorder that can cause optic nerve damage and impairment of his/her visual function which is called optic neuropathies (ON). Optic neuropathy refers to damage to the optic nerve (a cable connecting the eyes and the brain to transmit the visual signals) due to any cause.In this study, the investigator is using magnetic resonance imaging (MRI) and ophthalmic measures such as optic coherent tomography(OCT), which are non-invasive imaging tests to measure the changes in eye globe shape ,the flow of blood and brain fluid. It is hoped that this study will provide new knowledge that may allow the investigator to better understand the cause of symptoms associated with optic neuropathy and ways to better monitor what is happening.
Interventions
Radiographic imaging that takes about 30-45 minutes
DEVICEOptical Coherence Tomography (OCT)
Images taken from the back of the eye (retina)
Sponsors
University of Miami
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
: * 18 years old and on * Patients with optic neuropathy(10) and age controlled healthy subjects(10)
Exclusion criteria
: * For patients: Subjects with history of neurological or ocular disease other than optic neuropathy and refractory error. * For healthy control group: History of systemic disease except hypertension. * Pregnant women and prisoners will be excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Globe deformation | day 1 | Three measures of globe deformation are calculated by using the distance map: 1) optic nerve cupping(ONC), depicting the extent of the nerve head cupping; 2) posterior scleral bowing, depicting the degree of displacement of the posterior wall, and 3) maximal deformation (MD), depicting the combined deformation due to the displacement and the nerve cupping. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| intracranial pressure | Day 1 | Intracranial pressure will be measured using non invasive MRI. |
| Corneal thickness | Day 1 | Corneal thickness will be measured by corneal pachymetry. After anesthetic numbing drop is placed on the eye, blunt probe will briefly touch the participant's eye to obtain the measurement. |
| Visual field defect | Day 1 | Humphrey Field Analyzer II will be used to acquire the Mean deviation(MD). |
Countries
United States
Outcome results
None listed