Chromosome Abnormality, Twin Pregnancy With Antenatal Problem
Conditions
Brief summary
The risk of abnormal chromosome and structure is much higher in twins than in singletons, and traditional early pregnancy screening strategy for single pregnancy is not suitable for twins. Based on our management experience of fetal medicine at twin pregnancy, and multi-center cooperation, the study will carry out the following clinical studies: 1. to explore a suitable, early, noninvasive and accurate prenatal screening strategy for twin pregnancy. 2. fetal chromosomal abnormalities
Interventions
PROCEDUREFetal Selective Reduction Technology
Fetal Selective Reduction Technology will be conducted according to different gestational weeks: before 16weeks, 16\ 24 weeks, 24\ 27+6 weeks,\>28weeks
DRUGPotassium Chloride
Sponsors
Children's Hospital of Fudan University
International Peace Maternity and Child Health Hospital
Shanghai First Maternity and Infant Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* ultrasound diagnosis as twin pregnancy * at 11-14 gestational weeks
Exclusion criteria
* Multiple pregnancies (three or more) * Maternal history of chromosome aneuploidy abnormality or tumor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Success rate for the operation | 1 week |
Secondary
| Measure | Time frame |
|---|---|
| long-term complications after surgery | 1 year |
Outcome results
None listed