Dystonia, Dystonia, Secondary
Conditions
Brief summary
Dystonia is increasingly being considered as a multi-nodal network disorder involving both basal ganglia and cerebellar dysfunction. The aim of this study is to determine if Multi-Target Thalamic and Pallidal Deep Brain Stimulation improves hemi-dystonia patients who are receiving inadequate therapy from GPi DBS.
Interventions
DEVICEDeep Brain Stimulation
Deep Brain Stimulation Electrode
Sponsors
University of British Columbia
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. Diagnosed with hemi-dystonia secondary to stroke 2. Candidate for GPi DBS 3. Able to provide informed consent
Exclusion criteria
1. History of intracranial pathology (such as multiple sclerosis, tumors, or aneurysms) that may account for dystonia or essential tremor. 2. History or evidence of ongoing psychiatric or neurodegenerative disorders (such as Parkinson's disease, Alzheimer's disease). 3. Incompetent adults or those unable to communicate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Burke Fahn Marsden Disability Rating Scale (BFMDRS) | 3 months |
| SF-36 Quality of Life Scale | 3 months |
| Adverse effects of Vim or Vim + GPi Neuromodulation | 3 months |
Countries
Canada
Contacts
Primary ContactChris Honey, MD,DPhil,FRCSC
Backup ContactLeah Polyhronopoulos, BSc
Outcome results
None listed