Brain Injury, Chronic, Cerebral Palsy
Conditions
Brief summary
The aim of this study is to explore the relationship between brain MRI-metrics and hand function observed in children with cerebral palsy (CP),compared between baseline and the third month, and thus determine the early MRI-based neuroimaging predictor of clinical improvement following therapy in children with CP.
Detailed description
Cerebral palsy (CP) is the commonest cause of neurological disability in children. The upper limbs are often affected, with significant hand involvement from an early age.There are various methods of treatment for CP children with hand function disability. However, there is a lack of effective methods to predict the prognosis. This prospective cohort study will include children with occupational therapy (OT) or OT plus acupuncture and massage methods. Children with CP will be evaluated in terms of upper limb motor function using the manual ability classification system (MACS), fine motor function measure (FMFM). The Brain injuries of Children will be evaluated by MRI. The aim of this study is to explore the relationship between brain MRI-metrics and hand function, compared between baseline and the third month, and thus determine the early MRI-based neuroimaging predictors of clinical improvements following therapy in children with CP.
Interventions
BEHAVIORALOccupational therapy
OTHEROccupational therapy puls acupuncture and massage methods
Sponsors
Shenzhen Children's Hospital
General Hospital of Ningxia Medical University
Xijing Hospital
Second Affiliated Hospital of Wenzhou Medical University
Shaanxi Provincial People's Hospital
Baoji Central Hospital
Children's Hospital of Fudan University
Hainan People's Hospital
Zunyi Medical College
First Affiliated Hospital Xi'an Jiaotong University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
3 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Age: 3-18 years * Spastic cerebral palsy * The complete clinical and MRI data
Exclusion criteria
* previous acupuncture and massage methods * botulinum toxin upper limb injections * braces artifact, excessive motion, afraid to enter the MRI * parents were not interested in the MRI sessions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fine motor function measure (scores) | Baseline | It is acquired at baseline. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gross motor function measure and classification system (scores) | Baseline | It is acquired at baseline.The system is a 5 level clinical classification system that describes the gross motor function of people with cerebral palsy on the basis of self-initiated movement abilities. |
Countries
China
Contacts
Primary ContactJian Yang, Ph.D.,M.D.
Outcome results
None listed