Alzheimer Disease, Genetic Predisposition to Disease
Conditions
Keywords
Telemedicine, Counseling, Genetic
Brief summary
The purpose of this study is to compare two methods for remote genetic counseling (telephone and two-way videoconferencing) for patients who are receiving disclosure of their APOE (apolipoprotein E) genotype. The target population will consist of males and females in the age range of 60-75 years who, as potential participants in a study (Generation Study), will need to receive genetic counseling and disclosure of APOE genotype. Subjects must be willing to receive genetic counseling and disclosure remotely. Subjects must be willing to be randomized to either telephone arm or videoconference arm.
Interventions
OTHERTwo-way videoconference remote genetic counseling
OTHERTelephone remote genetic counseling
Sponsors
University of Pennsylvania
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
60 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
1. Eligible to participate in the Generation Study 2. Ability to provide consent 3. Ability to communicate and hear in English
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Satisfaction with genetic counseling services as measured by the Satisfaction with Genetic Services Scale | 2-7 days |
| Satisfaction with genetic counseling services as measured by the Satisfaction with Remote Counseling Scale | 2-7 days |
Secondary
| Measure | Time frame |
|---|---|
| Perceived risk of Alzheimers Disease as measured by questionnaire items measuring perceived risk in quantitative, qualitative, and relative terms | 2-7 days, 6 weeks, 6 months, 12 months |
| Responses to Genetic Testing as measured by the Impact of Genetic Testing for Alzheimer's disease (IGT-AD) scale | 2-7 days, 6 weeks, 6 months, 12 months |
| Knowledge of Genetic Disease as measured by the Cancer Genetics Knowledge Scale | 2-7 days, 6 weeks, 6 months, 12 months |
| Anxiety as measured by the Mini State Trait Anxiety Inventory (mSTAI): | 2-7 days, 6 weeks, 6 months, 12 months |
| Knowledge of Genetic Disease as measured by the ClinSeq Knowledge Scale | 2-7 days, 6 weeks, 6 months, 12 months |
| Depression as measured by the GDS Short Form | 2-7 days, 6 weeks, 6 months, 12 months |
| Disease-specific distress as measured by the Impact of Events Scale | 2-7 days, 6 weeks, 6 months, 12 months |
Outcome results
None listed