Acute Kidney Injury
Conditions
Brief summary
The investigators objective is to assess the utility of renal biomarkers in predicting renal recovery following institution of Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO). Tissue biomarkers of renal injury may provide a real-time indication of renal function and the likelihood of renal recovery in patients having cardiogenic shock and requiring VA-ECMO. In these patients, traditional markers of kidney function (urine output and serum Creatinine level) do not accurately represent renal function.
Interventions
OTHERbiomarker levels
The level of the biomarker hyaluronic acid will be measured
Sponsors
Milton S. Hershey Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* age more than 18 years * refractory or advanced cardiogenic shock prior to institution of VA-ECMO
Exclusion criteria
* History of chronic kidney disease prior to cardiogenic shock, as defined by estimated glomerular filtration rate (GFR) less than 60 mL per min * Cognitive impairment * Pregnant women * patient or surrogate is not fluent in English * Long-term immunosuppression
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| renal biomarker levels | through VA-ECMO decannulation, an average of 3 weeks | — |
| need for continuous renal replacement therapy at hospital discharge (Yes/No) | measured at hospital discharge, an average of 2-3 months following initial hospital admission | The need for continuous renal replacement therapy at hospital discharge will be assessed using hospital medical records |
Countries
United States
Outcome results
None listed