Ichthyosis Vulgaris
Conditions
Brief summary
A randomized double blinded clinical trial will be conducted comparing the effect of two simple basic moisturizers only different in the concentration of carbamide (urea). The concentrations of carbamide will be tested are 0 and 7.5, respectively. The study will be conducted as a split-body-study and will contain two arms randomized to comparing 0 and 7.5 % carbamide, respectively. Approximately 20 patients with at least clinically verified Ichthyosis Vulgaris will be enrolled to each study arm. The effect of the moisturizers will be assessed by clinical examination (score), patients assesment of effect and measurement of transepidermal water loss (TEWL) and other skin parameters.
Interventions
DEVICE7.5 %
Patient untreated with moisturizers for 1-2 weeks will start applying moisturizers containing urea at concentration 0 % on one half of the body twice a day while applying the same moisturizer with 7.5 % urea on the other half of the body in the same quantity at the same frequence
Sponsors
University of Aarhus
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Clinically diagnosed with Ichthyosis Vulgaris
Exclusion criteria
* All other forms of Ichthyosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Skin dryness | 2-8 weeks | Transepidermal water loss ('TEWL) (g/m2/h) |
Countries
Denmark
Outcome results
None listed