Postspinal Hypotension and Cardiac Performance in the Elderly

Is Postspinal Hypotension a Sign of Impaired Cardiac Performance in the Elderly? An Observational Mechanistic Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02978066

Enrollment

Registered

2016-11-30

Start date

2012-12-31

Completion date

2014-04-30

Last updated

2020-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ARTHROPLASTY, REPLACEMENT; ANESTHESIA

Brief summary

Patients, scheduled for elective arthroplasty were monitored with Lithium Dilution Cardiac Output monitor (LiDCOplus™) before and 45 minutes after spinal anesthesia. Hypotension was defined as systolic blood pressure ≤ 100 mmHg or ≥ 30% decrease from baseline. Associations between hypotension and the hemodynamic changes after preanaesthetic fluid loading and spinal anesthesia were analysed by logistic regression analyses.

Interventions

OTHERSpinal anaesthesia

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

* hip or knee arthroplasty * spinal anaesthesia * age 65 years or more

Exclusion criteria

* weight \<40kg * concomitant lithium medication * written informed consent not obtained * research team unavailable

Design outcomes

Primary

Measure	Time frame	Description
Stroke volume in ml	0-45 minutes after spinal anaesthesia	the blood volume pumped by the heart at each stroke

Secondary

Measure	Time frame	Description
Arterial blood pressure mmHg and change from baseline	0-45 minutes after spinal anaesthesia	mmHg measured by arterial catheter

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026