Juvenile Idiopathic Arthritis
Conditions
Keywords
Juvenile idiopathic arthritis, fat oxidation, exercise
Brief summary
During exercise, energy comes mainly from carbohydrates and lipids. The relative contribution of lipids and glucose as energy substrates to exercise depends on the parameters of the exercise (duration, intensity and level of training) and the physiological conditions of the subject. Inflammatory diseases such as juvenile idiopathic arthritis (JIA) are treated, for the most severe forms, by biotherapies. These treatments target certain pro-inflammatory cytokines including TNFα. In adults with rheumatoid arthritis several studies have shown that treatment with anti-TNFα increases insulin sensitivity. There is no data on the oxidation of energy substrates during exercise in children and adolescents with AJI, nor on the impact of anti-TNFα treatments on the oxidation of energetic substrates in children. Investigators hypothesize that, compared to healthy children, children with JIA should exhibit altered oxidation of energy substrates at rest and submaximal physical exercise due to physical deconditioning and inflammation. In addition, those treated with anti-TNFα should have an oxidation profile of energy substrates at exercise different from that of patients not treated with anti-TNFα. Investigators also hypothesize that anti-TNFα treatments modify the contribution of energy chains (aerobic, anaerobic and anaerobic alactic) during the exercise.
Detailed description
Annual evaluation by Lipoxmax test and Wingate anaerobic test (WAnT) during 3 years or until the transition from pediatric to adult care. For healthy volunteer, only one lipaxmax and Wingate test.
Interventions
OTHERanti-TNFα
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
8 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* Children with juvenile idiopathic arthritis
Exclusion criteria
* active infection * BMI \> 25 * Systemic corticosteroid within last 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage variation of the maximal fat oxidative rate during an exercise between JIA and healthy children. Timing: | at day 1 (first test) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Percentage variation of substrates oxidative crossing point during an exercise. | at day 1 | — |
| Description of the contribution of energy systems during supra-maximal physical exercise | at day 1 (first test) | Description of the contribution of energy systems during supra-maximal physical exercise in patients with JIA according to JIA subtype, treatments, age, pubertal status, disease status |
Countries
France
Contacts
Primary ContactPatrick LACARIN
Outcome results
None listed