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Ultrasound Guided TAP Block for Postoperative Analgesia After Abdominal Surgery.

Morphine as an Adjunct in Sonar Guided Transversus Abdominis Plane Block for Postoperative Analgesia in Patients Undergoing Abdominal Surgery.

Status
Completed
Phases
Phase 2Phase 3
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02976597
Acronym
TAB
Enrollment
90
Registered
2016-11-29
Start date
2016-11-30
Completion date
2018-07-31
Last updated
2018-12-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pain

Keywords

Abdominal surgery, pain, local, transversus abdominus block.

Brief summary

Transversus abdominis plane (TAP) block is a novel type of peripheral nerve block that involves innervations of the anterolateral abdominal wall derived from T6-L1.It provides adequate post-operative pain relieve following the various abdominal surgeries. Theoretically, TAP block may replace the need for epidural analgesia after abdominal operations. The oblique subcostal approach of the TAP (OSTAP) block, which was de¬scribed by (Hebbard et al, 2010) , has been reported to provide analgesia to the entire anterior abdomen.

Detailed description

The transversus abdominis plane (TAP) technique, originally described by involves injection of local anaesthetic in the plane between the internal oblique and transversus abdominis muscle layers, with the aim of anaesthetising the intercostal nerves supplying the abdominal wall. Initially, the block used surface landmarks of the triangle of Petit (latissimus dorsi posteriorly, external oblique superiorly, iliac crest inferiorly) and a double fascial 'pop' (loss of resistance) to guide placement of the local anaesthetic. More recently, ultrasonography has been used to guide the delivery of the injectate into the appropriate plane, thereby increasing the accuracy of the Technique. The duration of the TAB is limited to effect of administered local anesthetics. To prolong the block's duration, adjuvant medications were added to LA to magnify the effect of TAP block . Opiates such as morphine and tramadol have peripheral and central analgesic effects. Opiate receptors are present at the terminals of afferent peripheral nerves; therefore, administration of opiates peripherally might provide a significant analgesic effect.

Interventions

DRUGBupivacaine 0.25% 20ml on each side Sonar guided TAB

Bupivacaine 0.25% 20ml on each side Sonar guided TAP block. After careful aspiration injection of 20ml of 0.25% bupivacaine will be performed and hypoechoic layer will be detected on ultrasound then the maneuver will be repeated on the other side

Morphine 10mg will be added to bupivacaine in sonar guided- TAP block divided into 5mg on each side.

DRUGMorphine 15mg

Morphine 15mg will be added to bupivacaine in sonar guided- TAP block divided into 7.5mg on each side.

Sponsors

Assiut University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No

Inclusion criteria

BMI\< 30kg/m2. * Age: 18-60 years. * Sex: both males and females. * ASA physical status: 1-II. * Operation: Abdominal laparotomy.

Exclusion criteria

* Patient refusal. * History of cardiac disease, psychological disorders, respiratory diseases including asthma, renal or hepatic failure. * Coagulation disorders. * Allergy to study medications. * Chronic use of pain medications. * Pregnancy. * Respiratory tract in-fection within the last 2 weeks. * Heavy smoker. * Histo-ry of abdominal surgery or trauma.

Design outcomes

Primary

MeasureTime frameDescription
Verbal Rating Scale Score24 hoursThe 24 hours postoperative verbal rating scale score on cough

Secondary

MeasureTime frameDescription
Time to first request of rescue analgesia.24 hoursThe total 24 hours consumption of analgesic drugs taken.
Time to first request of rescue analgesics.24 hoursThe time from end of the operation, PACU admission and the request for analgesic drugs.
Spirometric assessment24 hoursMeasurment of lung function by spirometry.
Adverse effects24 hoursRecording and treatment of adverse effects.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026