Chronic Cor Pulmonale
Conditions
Brief summary
This study evaluates the effect of external diaphragmatic pacemaker on the patients with chronic cor pulmonale. Half of participants will receive external diaphragmatic pacemaker, while the other half will receive routine therapy.
Detailed description
Investigate the effect of external diaphragmatic pacemaker on chronic cor pulmonale, the indicators include: respiratory muscle force, diaphragmatic degree of excursion and thickness, pulmonary artery pressure, respiratory distress, feeling of fatigue and quality of life, pulmonary function,NT-proBNP,PaO2 and PaCO2.
Interventions
DEVICEexternal diaphragmatic pacemaker group
9 counts per minute, with stimulate frequency 40 Hz
Sponsors
Zhang Xiangyu
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* diagnosis of chronic cor pulmonale and admit to hospital
Exclusion criteria
* pneumothorax or mediastinal emphysema * active tuberculosis * install a cardiac pacemaker * acute cardiocerebrovascular events: acute myocardial infarction, acute myocarditis, severe arrhythmia, severe cerebrovascular accidents. * pregnancies * end-stage patients (expected survival time less than 6 months)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cardiopulmonary function | 10 days | six miunte walk test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| MIP | 10 DAYS | MAX INSPIRATORY PRESSURE |
Countries
China
Outcome results
None listed