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Comparison of Inflammatory Responses Subsequent to Different Cesarean Section Techniques

Comparison of Inflammatory Reactions Following Two Different Cesarean Surgery Techniques; The Modified Misgav-Ladach Versus the Pfannenstiel-Kerr Technique

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02976311
Acronym
C/S
Enrollment
88
Registered
2016-11-29
Start date
2016-04-30
Completion date
2016-09-30
Last updated
2016-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cesarean Delivery, Delivery, Inflammation

Keywords

inflammatory reaction, IL-6, TNF, Misgav Ladach technique, Pfannenstiel-Kerr technique, cesarean delivery, cesarean technique

Brief summary

In this study, the investigators aimed to find out whether there are any differences in inflammatory reactions occured subsequent to two different cesarean delivery techniques; modified Misgav-Ladach vs Pfannenstiel-Kerr techniques.

Detailed description

Cesarean section is one of the most undertaken operations in women of childbearing age. However, there is not a unique cesarean surgery technique. Pfannenstiel , reported his own technique in 1897. Because of the applicability of the technique, it went down well among obstetricians. After three decades, Kerr evolved this technique, and Pfannenstiel-Kerr technique became the method of choice until late 70's. In 1972, Stark et al defined the Misgav Ladach technique and in the following years this technique became popular among obstetricians. In late 80's Misgav Ladach technique was modified and started to be more popular. But, still Pfannenstiel-Kerr technique continued to be used frequently and studies comparing clinical outcomes of these two techniques were conducted for several times. However, the inflammatory responses which occured subsequent to application of these techniques were not investigated. This is the first study investigating the inflammatory response emerged after different cesarean surgery techniques.

Interventions

PROCEDUREcesarean section(C/S) via the modified Misgav-Ladach technique

the first consecutive 44 patients underwent C/S via the modified Misgav-Ladach technique

PROCEDUREcesarean section via the Pfannenstiel-Kerr technique

the second consecutive 44 patients underwent C/S via the Pfannenstiel-Kerr technique

Sponsors

Kayseri Education and Research Hospital
Lead SponsorOTHER_GOV

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Investigator)

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

* Cesarean section for the first time * Term,singleton pregnancy

Exclusion criteria

* Any inflammatory disease * Any pregnancy complication; IUGR,preeclampsia,preterm labor,preterm premature rupture of membranes * Pregnancies \<37weeks gestational age

Design outcomes

Primary

MeasureTime frameDescription
IL-624 hourspercentage of difference in serum IL-6 levels just before the beginning of the surgery and at the 24th hour of the surgery
TNF-alpha24 hourspercentage of difference in serum IL-6 levels just before the beginning of the surgery and at the 24th hour of the surgery

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026