Transcranial Magnetic Stimulation
Conditions
Keywords
cerebellum, supplementary motor area
Brief summary
In human, the physiology of gait and balance is not clearly established. By using functional imaging and electrophysiological techniques, various brain regions from the cortex to the midbrain area, including the cerebellum, have been identified as involved in such control. The specific role of these structures in both the capacity to go forward (locomotion) and stand upright (balance), but also in the different phases of the gait initiation process, are not known, however. In this study,the investigators aimed to assess the specific role of both the supplementary motor area (SMA) and the cerebellum in postural control during the initiation of gait. For this purpose, the investigators plan to study the gait initiation in 20 healthy subjects before and after functional inactivation (using inhibitory repetitive transcranial magnetic stimulation, rTMS) of the cerebellum or SMA. Biomechanical, kinematic and electromyographic parameters of the gait initiation will be recorded using a force platform, reflective markers with infrared cameras (VICON system) and lower limbs surface EMG electrodes.
Interventions
OTHERtranscranial magnetic stimulation
comparison of different conditions of transcranial magnetic stimulation
Sponsors
Institut National de la Santé Et de la Recherche Médicale, France
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-70 years * agree to participate to the study with signature of the informed consent * heathy insurance * normal clinical exam
Exclusion criteria
* previous medical history of neurological, rheumatological, orthopedic or psychiatric disorders * contra-indication to MRI or TMS * drug treatment that modifies the nervous central system excitability (antidepressant, antiepileptic, neuroleptic) * chronic alcoholism
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| postural control during gait initiation | change between baseline and 5 minutes after transcranial magnetic stimulation | braking capacity |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| duration of anticipatory postural adjustments | change between baseline and 5 minutes after transcranial magnetic stimulation | duration |
Other
| Measure | Time frame | Description |
|---|---|---|
| centre of foot pressure displacement during postural adjustments | change between baseline and 5 minutes after transcranial magnetic stimulation | centre of foot pressure displacement measured by force platform |
| step length | change between baseline and 5 minutes after transcranial magnetic stimulation | step length |
| step velocity | change between baseline and 5 minutes after transcranial magnetic stimulation | step velocity |
| duration of electromyographic activity of the tibialis anterior muscles | change between baseline and 5 minutes after magnetic transcranial stimulation | — |
Countries
France
Outcome results
None listed