Acute Respiratory Distress Syndrome
Conditions
Keywords
Acute Respiratory Distress Syndrome, epidemiology, clinical features, management, prognosis
Brief summary
ARDS is a critical respiratory disease caused by endogenous and exogenous factors. The mortality of ARDS varies from 30 to 70%. In 2012, a new international diagnostic criterion has been put forward. Yet, its feasibility, reliability and validity need to be tested. Meanwhile, the correlation of different severity and prognosis remains unclear. As so far, the epidemiological information about ARDS in China is lacking. Investigators plan to conduct a multi-center observational study（real-life study） to investigate the risk factors, morbidity, management and prognosis of ARDS in China, in order to facilitate standardization of diagnosis and management of ARDS and provide basic data and idea for further clinical intervention studies.
Interventions
None listed
Sponsors
PLA General Hospital
Second Xiangya Hospital of Central South University
Xiangya No.1 Hospital of Central South University
The Second Affiliated Hospital of Chongqing Medical University
Beijing Chao Yang Hospital
First Affiliated Hospital of Xinjiang Medical University
First Hospital Affiliated to China Medical University
Nanjing General Hospital
Peking University First Hospital
Third Hospital Affiliated to Neimenggu Medical University
Second Hospital Affiliated to Hebei Medical University
Qilu Hospital of Shandong University
First Hospital Affiliated to Anhui Medical University
Ruijin Hospital
Beijing Hospital
Peking Union Medical College Hospital
No.3 Hospital of Peking University
Fuxing Hospital
Fujian Provincial Hospital
China-Japan Friendship Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* ≥18 years of age; hospitalized patients with main diagnosis as ARDS.
Exclusion criteria
* \<18 years of age * Patients or their families refused to participate in the study * Patients diagnosed as COPD, pulmonary fibrosis or bronchiectasis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mortality | 28days | the 28days mortality after the diagnosis of ARDS |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Ventilation free days | 28 days | The days between successful weaning from mechanical ventilation and day 28 after study enrollment. |
| Incidence of ARDS | 2 years | The total number of acute respiratory distress syndrome(ARDS)patients in 2 years. |
| Severity of patients | 2 years | Number of patients in each grade of severities according to Berlin definition: the number of mild, moderate and severe acute respiratory distress syndrome(ARDS) patients will be recorded. |
| Adverse events related to treatment | 90 days | Number of patients with adverse events, include biotrauma, worsen of hemodynamics, hospital-acquired infection, patient-ventilator asynchrony, gastric distention, aspiration etc. |
| Number of patients using adjuvant drugs | 28 days | Adjuvant drugs refer to corticosteroid, sedative, analgesic and non depolarizing muscle relaxant. |
| Length of ICU stay | 90 days | The days between admission to intensive care unit(ICU) and discharge from ICU. |
| Number of patients with conventional respiratory support techniques | 28 days | Conventional respiratory support techniques include noninvasive positive pressure ventilation(NPPV), invasive positive pressure ventilation(include volume-controlled ventilation and pressure-controlled ventilation) . |
| Number of patients with unconventional respiratory support techniques | 28 days | Unconventional respiratory support techniques include recruitment maneuver(RM), prone position ventilation(PPV), high-frequency oscillatory ventilation(HFOV) ,extracorporeal membrane oxygenation(ECMO) and extracorporeal CO2 removal(ECCO2R) |
| Number of patients with impaired lung function | 90 days, 1 year | The number patients with impaired lung function 90 days and 1 year after diagnosis of acute respiratory distress syndrome(ARDS). |
| Number of patients with abnormal lung CT | 90 days, 1 year | The number patients with abnormal lung CT 90 days and 1 year after diagnosis of acute respiratory distress syndrome(ARDS). |
| Number of patients with high risk factors | 1 week | High risk factors for acute respiratory distress syndrome(ARDS), including endogenous factors as pneumonia, aspiration, lung contusion and drowning; the exogenous factors as extrapulmonary trauma, extra pulmonary sepsis , hypovolemic shock, pancreatitis, severe burning, drug overdose, blood transfusion，eclampsia etc. |
Countries
China
Contacts
Primary ContactHuang Xu
Backup ContactZhan Qingyuan
Outcome results
None listed