Transient Hypercalciuria
Conditions
Brief summary
Recommendations for vitamin D supplementation for subjets between 2 and 18 years offer strong sequential doses of vitamin D: 2 times 100 000 units in spaced winter period of 3 months. Data from the literature show a further increase in the incidence of oxalo-calcium stones in children and adolescents associated with hypercalciuria with training Randall plates, essential step lithogenesis calcium oxalate. Knowing the links between vitamin D and urinary calcium excretion, these data lead to the question of increased sensitivity in some children with vitamin D, sensitivity could explain these situations with hypercalciuria increase the gallstone risk. This increased sensitivity to vitamin D may unmask particularly if inputs of high doses of vitamin responsible then a transient hypercalciuria with development of microcrystals.
Interventions
DRUGCholecalciferol sequential dose
sequential dose administration of the treatment
DRUGCholecalciferol daily dose
daily dose administration of the treatment
Sponsors
University Hospital, Montpellier
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
2 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Children aged 2 to 17 years included * Obtaining informed consent of the parents signed * Participants aged 18 years included
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes from calcium level in urines at day 7, day 14 and day 28 | day 7, day 14 and day 28 |
Countries
France
Contacts
Primary ContactDenis MORIN, MD
Outcome results
None listed