Parkinson Disease
Conditions
Keywords
Parkinsons Disease, Cognition
Brief summary
Cognitive impairment in Parkinson's disease (PD) has far-reaching effects on both motor outcomes and quality of life in PD patients. Furthermore, deep brain stimulation (DBS), now an evidence-based treatment for certain cases of PD, has the risk of causing deficits in multiple areas of cognition. As such, the purpose of this study is to understand the neuroanatomical and neurophysiologic basis for impaired cognition in PD. The aim is to identify neural correlates of cognition by measuring brain signal activity while PD patients are engaged in cognition on a computer.
Detailed description
Study Participants: For this study, the investigators will recruit 75 Parkinson's disease (PD) patients that are undergoing deep brain stimulation (DBS) as routine standard of care. Screening: For healthy control participants, investigators will approach adults, aged 18-90, for possible involvement in our study. Potential participants will be asked if they have ever been diagnosed with a movement disorder, psychiatric disorder, or dementia. For PD patients undergoing evaluation for DBS, investigators will first consult with their neurologist and neurosurgeon. Next, investigators will approach the participant and explain the study. PD Participants: As part of the usual DBS process at University of Florida (UF), PD participants will be asked to participate in this trial. There are three evaluation time points: before surgery, during surgery, and possibly after surgery. Before surgery, the PD patients will complete standardized questionnaires and be trained on a computer game to assess cognition. During surgery, the participants will play the same computer game while brain signals are recorded. When the patients return to University of Florida for DBS programming visits within 48 months after surgery, they will repeat the standardized questionnaires and computer game once again.
Interventions
BEHAVIORALComputer task assessing cognition
Participants will complete a short computer game to assess cognition.
BEHAVIORALImpulsive-Compulsive Disorders in Parkinson's Disease
Standard clinical questionnaire
PROCEDUREDeep Brain Stimulation Surgery
DBS surgery for the implantation of electrodes for the treatment of motor disorders.
Sponsors
National Institute of Neurological Disorders and Stroke (NINDS)
University of Florida
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
PD-DBS Participants: * Inclusion Criteria: Persons undergoing DBS surgery for the implantation of electrodes for the treatment of motor disorders *
Exclusion criteria
Failure of the DBS surgical candidacy screening process Non-DBS PD Participants: * Inclusion Criteria:Persons diagnosed with idiopathic Parkinson's disease and have not received and are not currently scheduled for DBS. *
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in behavioral performance | Baseline, before surgery, during surgery, and up to 2 years after surgery | Behavioral performance will be assessed by the computer game that assess cognition. All computer games used in this study will have a similar form. The computer will record responses to each trial during the computer game. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Score on Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease - Rating Scale (QUIP-RS) | Baseline, before surgery, during surgery, and up to 2 years after surgery | Assess the scores from a standard clinical questionnaire called QUIP-RS. Scores range from 0 to 112. |
| Local field potential brain signal | At time of surgery | Measuring Brain signal while Parkinson's disease patients play a computer game during surgery. Local field potential is measured in Hertz (Hz) |
Countries
United States
Outcome results
None listed