The Effects of Lactobacillus Plantarum on Cortisol, IgA and Alpha-amylase Levels in Human Saliva During Stress

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02974894

Enrollment

Registered

2016-11-29

Start date

2013-02-28

Completion date

2013-05-31

Last updated

2016-12-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stress Reaction

Brief summary

In the present study the main goal has been to clarify the effect of the probiotic bacteria Lactobacillus plantarum 299v on the salivary cortisol level in young adults under examination stress. Salivary IgA from minor glands and in whole human saliva was measured as alternative marker of stress. The hypothesis was that the levels of cortisol would be reduced or stabilized in the test group in comparison to the placebo group where the cortisol levels were expected to increase due to the examination-induced stress. By contrast, the salivary IgA levels were expected to increase in the test group in comparison to the placebo group.

Interventions

DIETARY_SUPPLEMENTProbiotic (Lactobacillus Plantarum)

DIETARY_SUPPLEMENTPlacebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* adults * studying at the University in Lund * participation in ongoing examination period

Exclusion criteria

* pregnancy * intake of antibiotics * medication with cortisone during the study period

Design outcomes

Primary

Measure	Time frame
The impact of Lactobacillus plantarum on the levels of stress-induced cortisol in saliva.	Change from baseline in cortisol levels at 14 days

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 2, 2026