Stroke, Swallowing Disorders
Conditions
Brief summary
The oropharyngeal junction participates in 3 interpenetrating functions: Swallowing, Breathing and Speech. In the context of ischemic or hemorrhagic stroke, these are altered, isolated or associated manner, causing major disorders and representing a source of handicap for patients. Understanding the swallowing mechanisms is therefore a major challenge to guide the rehabilitation and improve the initial and long-term prognosis of patients with stroke. The main objective of this study is to describe and modeling, thanks to a clinical, physiological and radiological knowledge base, swallowing, speech and breathing, in patients with stroke and in healthy subjects.
Interventions
OTHERLaryngological evaluation
OTHERMRI evaluation
OTHERBreathing investigation
OTHERMRI and articulatory investigation
OTHERPostural investigation
OTHERVoice and soundscape investigation
Sponsors
National Research Agency, France
University Hospital, Caen
University Hospital, Montpellier
Centre Hospitalier du Pays d'Aix
Université Joseph Fourier
University Hospital, Grenoble
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
For patients after stroke Inclusion Criteria: * First stroke confirmed by MRI \< 15 days * No severe leukoaraiosis * Swallowing disorders identified (GUSS scale \< 20) * Neurological deficit identified (NIHSS scale \<15) * Patient able to cooperate for investigations * Informed consent signed
Exclusion criteria
* Cerebral hemorrhage * History of neurological disease that can lead to swallowing disorders * History of laryngological disease such as previous surgery or radiation neck * Tracheotomy * Vigilance disorders * Pregnant, parturient or nursing woman * Protected adult * Simultaneous participation in another study * Non registered to the French social security system For healthy subjects Inclusion Criteria : * Age between 18 and 40 years old * French native speaker * Normal hearing with or without corrective * No oral or written language disorders * No neurological or psychiatric disorders * Informed consent signed
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of Clinical severity score | At inclusion and 6 months after diagnosis | NIHSS scale |
| Change of swallowing disorder | Within 15 days after diagnosis and 6 months after diagnosis | Test : GUgging Swallowing Screen |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of aphasia disorder | Within 15 days after diagnosis and 6 months after diagnosis | Questionnaire : Aphasia rapid test |
| Change of behavioural attention | Within 15 days after diagnosis and 6 months after diagnosis | Questionnaire : Catherine Bergego scale |
| Change of state of depression and anxiety | Within 15 days after diagnosis and 6 months after diagnosis | Questionnaire : anxiety and depression scale |
Countries
France
Contacts
Primary ContactMarc Hommel, MD
Backup ContactPhilippe Cousin
Outcome results
None listed