Healthy
Conditions
Keywords
orange juice consumption, glucose homeostasis, antioxidative status
Brief summary
Aim of the study is to investigate the impact of orange juice consumption (with meals or between meals) as well as sugar sweetened beverage (SSB) consumption (between meals) on glucose homeostasis and antioxidative status.
Detailed description
Duration of the study is 3x three weeks including one wash-out week each followed by two weeks of juice/SSB consumption under free living conditions. During wash-out weeks consumption of orange juice or citrus fruits is restricted. During intervention weeks, participants are asked to eat three regular meals per day without snacking. Intervention weeks are (i) orange juice consumption with meals (ii) orange juice consumption between meals and (iii) SSB consumption between meals. Daily energy intake with orange juice/SSB is 20% of individual energy requirement. Additional caloric beverages (SSB, juice, coffee with sugar/milk, alcohol) are not allowed. At the beginning and the end of each intervention phase insulin sensitivity and antioxidative status are assessed.
Interventions
DIETARY_SUPPLEMENTOrange juice with meals
orange juice (20% of energy requirement/day)
DIETARY_SUPPLEMENTOrange juice between meals
orange juice (20% of energy requirement/day)
DIETARY_SUPPLEMENTSugar sweetened beverage between meals
Sugar sweetened beverage (20% of energy requirement/day)
Sponsors
University of Hohenheim
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy
Exclusion criteria
* regular use of medication, * smoking, * chronic disease, * vegan/vegetarian diet, * fructose intolerance, * irregular eating behaviour (less then 3 meals/day)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes in daylong glycaemia between pre and post intervention periods | two weeks | measured via continuous glucose monitoring \[mg/dL\] |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| changes in uric acid between pre and post intervention periods | two weeks | measured via uric acid serum levels \[mg/dL\] |
| changes in insulin sensitivity between pre and post intervention periods | two weeks | measured via Matsuda-Index from oral glucose tolerance test data |
| changes in antioxidative status between pre and post intervention periods | two weeks | measured via vitamin c blood levels \[mg/L\] |
Countries
Germany
Outcome results
None listed