Healthy Volunteer, High-frequency Ventilation, Non-invasive Ventilation
Conditions
Keywords
MRI, Chest, Apnea
Brief summary
The purpose of the study is to evaluate the benefit on image quality of MRI of the chest performed under high frequency non-invasive ventilation. This technique indeed allows to generate an apnea duration of several minutes with acquisitions performed at full inspiration. This study will be applied on healthy subjects.
Detailed description
High frequency ventilation (HF-V) has been applied by using a non-invasive interface allowing to obtain a prolonged apnea in awaken subjects. Such an application should be of interest for MRI taking into account its susceptibility to motion of the chest and the imperfect techniques of respiratory gating that are usually performed at end expiration. The purpose of this study is to assess the benefit on image quality of different sequences performed with and without the device in healthy subjects.
Interventions
DEVICEMRI with High-frequency non-invasive ventilation
MRI performed under high-frequency non-invasive ventilation
OTHERMRI without High-frequency non-invasive ventilation
MRI performed without High-frequency non-invasive ventilation
Sponsors
University of Lausanne Hospitals
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy subjets : normal respiratory function and no known lung disease * Age \>=18y
Exclusion criteria
• Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Image quality assessment (soapbubble, maximum of first derivative, signal to noise, contrast to noise) | within 2 weeks after MRI acquisition | Image quality and artefacts will be evaluated and compared without and with the device. Sharpness of the interfaces between vessels and lung will be evaluated with the Soapbubble software (Etienne et al., Magn Reson Med. 2002 Oct;48(4):658-66). The interface between diaphragm and lung will be evaluated with the maximum of the first derivative (Tibiletti et al., Magn Reson Med. 2016 Mar;75(3):1324-32). Signal to noise and contrast to noise will be measured within regions of interest in the image. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart and coronary arteries evaluation (soapbubble, signal to noise, contrast to noise) | within 2 weeks after MRI acquisition | The potential benefit on the exploration of the heart and coronary arteries will be assessed. Sharpness of the coronary arteries with respect to the neighbouring tissue will be evaluated with the Soapbubble software (Etienne et al., Magn Reson Med. 2002 Oct;48(4):658-66). Signal to noise and contrast to noise will be measured within regions of interest in the image. |
| Synchronization of the acquisition | during the MRI examination | The possibility of synchronizing the MRI acquisition with the ventilation system will be explored with the aim to eliminate residual diaphragmatic motion and evaluate the potential additional benefit in terms of image quality and artefacts will be evaluated. |
| Subjective tolerance (questionnaire) | at the end of the MRI examination | Subjective tolerance of MRI examination under HF-NIV (questionnaire). Participants will fill the questionnaire right after the examination end. |
Countries
Switzerland
Outcome results
None listed