Salt Intake and Lactobacillus Abundance

Influence of Increased Salt Intake on Lactobacillus Abundance in Healthy Men

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02971787

Enrollment

Registered

2016-11-23

Start date

2016-11-30

Completion date

2017-06-30

Last updated

2022-07-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Volunteers, Probiotics, Sodium

Brief summary

To investigate the influence of an increased salt intake (6 g/d for 14 days) on the relative abundance of gut lactobillus species in healthy men

Interventions

DIETARY_SUPPLEMENTProbiotics

Day 1-21: 2 capsules per day

DIETARY_SUPPLEMENTSalt

Day 8-21: 10 tablets à 600 mg per day

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy men * 18 - 50 years * Body mass index 18,5 - 29,9 kg/m2

Exclusion criteria

* Clinically relevant heart, lung, liver, and kidney disease * Current or chronic infections * Habitual intake of probiotics or dietary supplements

Design outcomes

Primary

Measure	Time frame
Decrease of relative abundance of four lactobacillus species	14 days

Secondary

Measure	Time frame
Increase of systolic blood pressure	14 days
Increase of pulse wave velocity	14 days
Increase of lymphocytic pro-inflammatory mediators	14 days

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 24, 2026