Locally Advanced and Metastatic Prostate Cancer
Conditions
Brief summary
Prostate cancer is the most common non-skin cancer diagnosed among men and the second leading cause of male cancer deaths in the United States. In 2013, it is estimated that 29,270 men have died from prostate cancer. Although radiation and surgery are quite effective for localized disease, there is no effective cure for men who present with metastatic prostate cancer as the 5-year relative survival rate is only 28%. Currently, androgen deprivation therapy (ADT) via medical or surgical castration is the standard first-line therapy in men with metastatic disease but castration-recurrent prostate cancer (CRPC) eventually emerges with a median time of 18-24 months. Once CRPC develops, secondary hormonal manipulation, chemotherapy, and immunotherapy are marginally effective. Given the dismal prognosis of metastatic prostate cancer, new ideas and novel approaches must be explored to improve the clinical outcome. In this regard, recently emerging data suggest that local tumor control may enhance the effectiveness of subsequent systemic therapies. Therefore, in this proposal, the investigators have designed a Phase I/II study in which they will prospectively evaluate the safety and feasibility of cytoreductive prostatectomy in men with newly diagnosed mPCa.
Interventions
PROCEDURERadical prostatectomy
Standard radical prostatectomy with extended lymph node dissection is performed.
Sponsors
Medical University of Vienna
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Adenocarcinoma of the prostate * Very high risk PCA (PSA ≥ 20 oder Gleason Score ≥ 8 oder ≥ cT3) and/or oligometastasierte PCA (T any N positive M any, oder T any N any M positive) * ≤5 bone metastasis * ≤75 years * Ability for informed consent * Clinically no infiltration into the rectum or pelvic wall * Clinically no visceral metastasis * Male, \>18 Jahre * Fit for surgery * ECOG Performance Status 0 oder 1
Exclusion criteria
* Male, \< 18 Jahre * \> 5 bone metastasis * \> 75 years * No ability for informed consent * Clinically infiltration into the rectum or pelvic wall * Not fit for surgery * Clinically visceral metastasis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of perioperative complications within 90 days after surgery (Clavien-Dindo-classification) | 90 |
Secondary
| Measure | Time frame |
|---|---|
| Time to start androgen deprivation therapy | 2 years |
Countries
Austria
Outcome results
None listed