Fertilization in Vitro
Conditions
Brief summary
Exposure to heavy metals may interfere with basic cellular functions, including DNA synthesis. The aim of the study is to correlate heavy metals concentration in body fluids of reproductive importance and IVF outcome.
Detailed description
Concentration of heavy metals will be measured in blood, urine, semen fluid and follicular fluid of IVF patients. Study group: poor prognosis patients: repeated IVF failure, implantation failure, poor ovarian response, low sperm quality (according to WHO criteria) Control group: Good prognosis patients. Normal sperm count. Heavy metals concentrations will be measured using atomic absorption spectrometer, and will be correlated with IVF outcomes: number of mature oocytes obtained, fertilizations, embryos quality, and reproductive outcome post embryo transfer.
Interventions
None listed
Sponsors
Rambam Health Care Campus
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Age of female patients: \<=39 * Age of male patients: 18-50
Exclusion criteria
* Smoking * Alcohol/drug abuse * Long-term/chronic medications * Severe health/mental problems * Dental or other transplants * Fragile X mutations * Fertility preservation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Live birth rate (take-home baby) | 9 months from embryo transfer | IVF cycle resulting in pregnancy that ends in a live birth. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical pregnancy rate | 1 month from embryo transfer | Gestational sac(s) seen by ultrasound 1 month after embryo transfer. |
Contacts
Primary ContactShahar Kol, MD
Outcome results
None listed