Colorectal Cancer
Conditions
Keywords
Escherichia coli, Microbiota, Colorectal cancer, Psychiatric disorders, Personality traits
Brief summary
The purpose of this study is to determine whether the presence of pathogenic Escherichia coli in colon is associated with psychiatric disorders.
Detailed description
Colonic colonization by pathogenic Escherichia coli was determined when patients were operated on for colorectal cancer. Several years later, the investigator investigate past and actual psychiatric disorder using the Mini International Neuropsychiatric Interview (MINI). Actual depression and anxiety scores are evaluated with Hamilton scales and personality traits are investigated using Personality Inventory for DSM-5 (PID-5). Anxiety and depression scores, psychiatric diagnoses (MINI) and personality traits were compared in patients according to Escherichia coli presence/absence.
Interventions
The purpose of this study is to determine whether the presence of pathogenic Escherichia coli in colon is associated with psychiatric disorders.
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients operated on for colorectal cancer in the digestive surgery department of Clermont-Ferrand hospital * patients older than 18 years, * patients whose Escherichia coli colonization was analyzed after surgery * patients which are always followed by the digestive surgery department.
Exclusion criteria
* Patients with dementia will not be included, according to the MMSE score: * 22 if no grade * 23 if study certificate or CAP or college without patent * 25 if patent or school without the tray * 26 or more when bin
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hamilton anxiety and depression score comparison | at day 1 | Hamilton anxiety and depression score will be compared between patients with Escherichi coli colonic colonization and patients without Escherichi coli |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Psychiatric prevalence comparison | at day 1 | prevalence of each past and actual psychiatric disorder diagnosed by the Mini International Neuropsychiatric Interview (MINI: major depression, dysthymia, suicidal risk, hypomania, mania, panic disorder, agoraphobia, social phobia, specific phobia, obsessive-compulsive disorder, posttraumatic stress disorder, dependence and abuse of alcohol, tobacco- dependence, psychotic disorders and generalized anxiety disorder) will be compared in patients according to colonic colonization by Escherichia coli. |
| personality traits comparison | at day 1 | personality traits investigated using Personality Inventory for DSM-5 (PID-5) will be compared in patients according colonic colonization by Escherichia coli |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORIsabelle JALENQUES
University Hospital, Clermont-Ferrand
Outcome results
None listed