Chronic Heart Failure, Metabolic Syndrome
Conditions
Keywords
heart failure, heart disease, cardiovascular disease, metabolic risk, comorbidities
Brief summary
Follow-up of two hospital-based patient cohorts (heart failure, metabolic comorbidities in CVD), recruited at baseline by the GANI\_MED-project (Greifswald Approach to Individualized Medicine). Standardized protocols will be used for the assessment of medical history, laboratory biomarkers, and the collection of various biosamples for bio-banking purposes. Comparisons with the general background population will be performed.
Detailed description
5-year follow-up of two hospital-based patient cohorts (heart failure, metabolic comorbidities in CVD), recruited at baseline by the GANI\_MED-project (Greifswald Approach to Individualized Medicine). Subjects will be comprehensively phenotypes using standardized protocols for the assessment of medical history, laboratory biomarkers, and the collection of various biosamples for bio-banking purposes. A multi-omics based biomarker assessment including genome-wide genotyping, transcriptome, metabolome, and proteome analyses complements the multi-level approach of GANI\_MED. Comparisons with the general background population as characterized by the Study of Health in Pomerania (SHIP) will be performed.
Interventions
no intervention, only observational
Sponsors
University Medicine Greifswald
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Participation in baseline examination of GANI\_MED cohorts (heart failure, metabolic risk)
Exclusion criteria
* none
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cardiovascular events | 1-year follow-ups | Hospitalization (HF based. all-cause), myocardial infarction |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| VO2peak | 1-year follow-ups | Exercise capacity by CPET |
| QOL | 1-year follow-ups | Quality of life by questionnaire (Minnesota Living with heart failure questionnaire) |
| 6MW | 1-year follow-ups | 6 minute walk test distance |
| LVEF | 1-year follow-ups | Left ventricular ejection fraction by echo at time of follow-up |
Other
| Measure | Time frame | Description |
|---|---|---|
| PWA | 1-year follow-ups | pulse wave analysis parameters by Vascular Explorer device (neverdis GmbH, Germany) |
Countries
Germany
Contacts
Primary ContactMarcus Dörr, MD
Backup ContactStephan B Felix, MD
Outcome results
None listed