Healthy
Conditions
Keywords
PET/MRI, muscular activity, 11C-acetate
Brief summary
The present study is conceived as a pilot study aimed to determine the efficiency of the newly available Positron Emission Tomography (PET) - Magnetic Resonance Imaging (MRI) hybrid scan technique for muscular activity evaluation, creation of anatomic images of muscle activity and resolution of metabolic activity distribution within exercising skeletal muscle.
Interventions
OTHERMagnetic Resonance Imaging
Magnetic Resonance Imaging as reference
OTHERMagnetic Resonance combined with Positron Emission Tomography
Comparison with MRI only, to assess muscular activity, creation of anatomic images of muscle activity and resolution of metabolic activity distribution within exercising skeletal muscle
Sponsors
Osman Ratib
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
MRI exam inclusion criteria * Male volunteer aged in the range 18 to 35 years. * Acceptance of the research protocol: signature of the informed consent form after oral and written information about the protocol through the patient information document. * Volunteers that could undergo 1h15 to 1h30 immobilization (MRI exam duration in time). PET/MRI exam inclusion criteria * Male volunteer aged in the range 18 to 35 years. * Acceptance of the research protocol: signature of the informed consent form after oral and written information about the protocol through the patient information document. * Volunteers that could undergo 1.5 to 2.0 hours immobilization (PET/MRI exam duration in time). * Volunteers should practice regular physical activity, defined as 50 min per day (in a single session), 2 days per week of physical activity as a minimum (no maximum is fixed).
Exclusion criteria
MRI exam
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of musculoskeletal systems in motion | though study completion, an average of 2 years | an informatic visualization tool of muscles implied in leg flexion/extension combining PET and MR infomation |
| Distribution of acetate metabolism during exercise skeletal muscle | though study completion, an average of 2 years | 11C-acetate uptake (SUV and SUVratio with resting muscles) in contracting muscle, measured using muscle segmentation from MRI images |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of the in vivo function of the muscle | though study completion, an average of 2 years | correlation between 11C-acetate uptake and contractile force measures (weight and duration of exercise) |
Countries
Switzerland
Outcome results
None listed