Management of Third-stage of Labor After Second Trimester Medical Pregnancy Termination

Effect of Intra-venous Oxytocin Injection After Fetal Expulsion in Management of Third-stage of Labor After Second Trimester Medical Pregnancy Termination

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02969447

Acronym

ANDDROID

Enrollment

Registered

2016-11-21

Start date

2016-10-20

Completion date

2017-08-04

Last updated

2026-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Retained Placenta

Keywords

Retained Placenta, Second trimester medical termination, Third stage labor, Oxytocin

Brief summary

Prospective randomized trail which compare 2 regimens for third-stage management after second trimester medical pregnancy termination : 10UI intra venous oxytocin or no additional medication after fetal expulsion. Primary outcome was the incidence of placental retention.

Detailed description

Complication of third stage of labor in second trimester medical pregnancy termination is not well studied. Accord to publications, the placental retention rate is 30 to 40% in these situations. Placental retention may be associated with increased blood loss, increased requirement for blood transfusion anesthetic and operative complications, and infectious morbidity. The high incidence of retained placenta is an area of clinical concern. Publications reveal a wide variation in practices but there are only few studies about third stage of labor in second trimester medical pregnancy termination. The study is a prospective randomized trial. Two third stage management strategies are compared: 10 units of intra venous oxytocin (group 1) and no additional medication (group 2) after fetal expulsion. It concerns pregnancies between 14 and 28 weeks gestation.

Interventions

DRUGAdministration of 10 units of intra venous oxytocin after fetal expulsion

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* 18 years old and older * medical pregnancy termination between 14 and 28 weeks gestation * informed consent obtained

Exclusion criteria

* less than 18 years old * refusal to consent * in utero fetal death

Design outcomes

Primary

Measure	Time frame
Incidence of placental retention	Up to 30 minutes after fetal expulsion

Secondary

Measure	Time frame
Incidence of partial placental retention	Up to 1 hour after fetal expulsion
Incidence of digital exploration	Up to 1 hour after fetal expulsion
Incidence of blunt curettage	Up to 1 hour after fetal expulsion
Incidence of post-partum hemorrhage	Up to 1 hour after fetal expulsion
Blood loss	Up to 1 hour after fetal expulsion

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 13, 2026