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Effect of Peripheral Electrical Stimulation (PES) on Brain Response to Glucose Stimuli

Effect of Short Peripheral Electrical Stimulation (PES) on Brain Response to Glucose Stimuli Evaluated by BOLD and Functional Diffusion MRI: a Crossover Pilot Study

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02969330
Enrollment
20
Registered
2016-11-21
Start date
2016-12-31
Completion date
Unknown
Last updated
2016-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain Activity, Glucose Control

Brief summary

The aims of this study are twofold: (1) to develop an innovative approach for studying brain glucose metabolism using functional diffusion weighted imaging (DWI) and BOLD fMRI in humans; (2) to evaluate the effect of short peripheral electrical stimulation (PES) treatment on brain and brain-stem targets, associated with control of food intake and energy expenditure, in response to glucose stimuli, in healthy volunteers.

Interventions

DEVICEStimulator
DIETARY_SUPPLEMENTGlucose

300ml tap water with 75g glucose

Sponsors

Sheba Medical Center
CollaboratorOTHER_GOV
Tel Aviv University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes

Inclusion criteria

* Healthy volunteers * Age 18-65 years old. * Body mass index 18 to 25 kg/m2 * Capable of giving informed consent

Exclusion criteria

* Pregnancy, or nursing * Permanent pacemakers * Metal prosthesis * Skin disease * Claustrophobia * History of neurological disorders

Design outcomes

Primary

MeasureTime frame
Changes in postprandial cerebral blood flow (fMRI) and cerebral diffusivity (fDWI) in response to glucose ingestion.changes from baseline to 30 minutes after glucose ingestion

Contacts

Primary ContactUri Nevo, PhD
nevouri@post.tau.ac.il972-3-6407542

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026