Liver Neoplasms
Conditions
Brief summary
The purpose of this study is to evaluate the safety and efficacy of targeted cryoablation therapy for hepatic carcinoma.
Detailed description
A cryoprobe is inserted percutaneously under CT guidance into the targeted lesion. Patients undergo ablation using a freeze-thaw-freeze cycle lasting approximately 10-6-10minutes.
Interventions
PROCEDURETargeted Cryoablation Therapy
A cryoprobe is inserted percutaneously under CT guidance into the targeted lesion. Patients undergo ablation using a freeze-thaw-freeze cycle lasting approximately 6-10-6 or 8-10-8 minutes, respectively.
Sponsors
Shanghai University of Traditional Chinese Medicine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of liver cancer based on histology or the current accepted radiological measures. * Single Tumor size ≤5.0 cm in greatest diameter, or multiple tumor number≤3 and each tumor size≤ 3cm. * Life expectancy: Greater than 3 months. * Patients' liver function is Child-pugh A or B. * Ability to understand the study protocol and a willingness to sign a written informed consent document. * Unable to receive operative surgery.
Exclusion criteria
* Patients with other primary tumor except liver cancer. * History of coagulation disorders or anemia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of complete tumor ablation | Up to 4 weeks post surgery |
Secondary
| Measure | Time frame |
|---|---|
| Adverse Events | Up to 4 weeks post surgery |
Countries
China
Outcome results
None listed