Ischemic Heart Disease
Conditions
Keywords
Coronary artery disease, Cardiac perfusion SPECT, Metabolomics
Brief summary
The aim of this study is to analyze metabolomic pattern of patients after cardiac stress in order to detect differences based on the type of stress (physical or pharmacological with adenosine agonists) and result of test (positive or negative for ischemia) and to indentify biochemical markers with prognostic value. Clinical data of enrolled patients regarding demographics, cardiovascular risk factors, pretest probability and previous cardiovascular disease will be recorded. Follow up will be at one, three and five years and will be performed by clinical recordings or phone call when necessary. Blood samples of patients undergoing myocardial perfusion SPECT (Single Photon Emission Computed Tomography) are taken before, immediately after stress and 2h after stress. Serum samples will be analyzed by nuclear magnetic resonance in order to know metabolomic profile.
Detailed description
The aim of this study is to analyze metabolomic pattern of patients after cardiac stress in order to detect differences based on the type of stress (physical or pharmacological with adenosine agonists) and result of test (positive or negative for ischemia) and to indentify biochemical markers with prognostic value. Clinical data of enrolled patients regarding demographics, cardiovascular risk factors, pretest probability and previous cardiovascular disease will be recorded. Follow up will be at one, three and five years and will be performed by clinical recordings or phone call when necessary. Blood samples of patients undergoing myocardial perfusion SPECT are taken before, immediately after stress and 2h after stress. Serum samples will be analyzed by nuclear magnetic resonance in order to know metabolomic profile.
Interventions
OTHERNon intervention
Sponsors
Hospital Universitari Vall d'Hebron Research Institute
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients men or women ≥ 18 years of age * Patients with prescription of cardiac perfusion SPECT
Exclusion criteria
* Patients with loss of consciousness or confuse, not able to read the information and to sign the writting consent * Pregnant women * Patients with dobutamine indications in the stress protocol
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Result of myocardial perfusion SPECT: positive or negative for angina, ischemia or perfusion defect. | 2 days | — |
| Metabolomic profile on NMR (Nuclear Magnetic Resonance ) analysis of serum sample | 6 month | Once all samples analyzed, in order to identify of specific patterns associated to any group (type of test or result of test). |
Secondary
| Measure | Time frame |
|---|---|
| Combined end point: Cardiovascular death, Myocardial infarction, Coronary revascularization. | 1 year |
| Angina treatment initiation | 1 year |
| Metabolomic profile on NMR analysis of serum sample | 1 year |
Countries
Spain
Outcome results
None listed